As [#Dictionary(SirSpheresR)] são dispositivos médicos usados na Radioterapia Interna Seletiva (Selective Internal Radiation Therapy - SIRT) para tumores no fígado.

  • As [#Dictionary(SirSpheres)]são implantes permanentes e somente para uso único.
  • As microesferas de resina biocompatíveis contendo ítrio-90 têm um diâmetro mediano de 32,5 micra (faixa de 20 a 60 micra).

O ítrio-90 é um isótopo que emite radiação beta de alta energia sem emissão primária de raios gama.

  • A energia máxima das partículas beta é de 2,27 MeV com uma média de 0,93 MeV.
  • O alcance máximo das emissões em tecido é de 11 mm com uma média de 2,5 mm.
  • A meia vida é de 64,1 horas. Após a administração, 94% da radiação são emitidos em 11 dias.

Essas propriedades das [#Dictionary(SirSpheres)] indicam que elas se alojam preferencialmente na microvascularização que circunda o tumor, maximizando os efeitos tumoricidas e minimizando os efeitos no parênquima saudável do fígado (consulte também Modos de Ação e Aspectos de Segurança de Radiação).




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