The angiographic procedure for delivering the SIR-Spheres® Y-90 resin microspheres is similar to the work-up, or mapping, angiogram. Once the microcatheter has been correctly sited in the hepatic artery, the proximal end of the microcatheter is connected to the SIR-Spheres Y-90 resin microspheres Delivery System. SIR-Spheres Y-90 resin microspheres are then slowly delivered into the trans-femoral catheter. The radiologist should periodically check the position of the microcatheter to ensure it remains correctly sited during the delivery procedure and confirm that blood is flowing forward without stasis.

SIR-Spheres Y-90 resin microspheres are delivered slowly at a rate of no more than 5mL per minute to allow for optimal distribution in the tumor microvasculature.  Too rapid delivery of microspheres may cause reflux back down the artery into other organs. At the conclusion of the procedure, the microcatheter is removed and the patient returned to the ward for observation before discharge.  A SPECT scan of the upper abdomen may be performed within 24 hours after implantation of SIR-Spheres Y-90 resin microspheres. The SPECT scan will detect the Bremsstrahlung radiation from the yttrium-90 to confirm placement of the microspheres in the liver.

For details of the SIR-Spheres Y-90 resin microspheres administration procedure please contact your local Sirtex representative or contact us.

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