Selective Internal Radiation Therapy (SIRT), also known as Radioembolization, is a liver-directed therapy for inoperable liver tumors. SIRT is administered by a specially trained Interventional Radiologist.
A microcatheter is used to deliver millions of radioactive microspheres into the hepatic artery, where they are carried into the arterioles and selectively lodge in the tumor microvasculature (for further information see Mode of Action).
- Increase the time to progression
- Extend overall survival
- Potentially downsize or downstage tumors for liver resection, ablation, or transplantation
- Provide palliation of symptoms
SIRT can be combined with modern chemotherapy or administered as a monotherapy, either during a chemotherapy holiday, in a salvage setting or as an alternative to local chemotherapy.
Radiotherapy, together with chemotherapy and surgery, is a major pillar in the treatment of cancer. However, the utility of external beam radiation in the management of liver tumors is limited by the sensitivity of the uninvolved liver parenchyma to radiation. Selective Internal Radiation Therapy with SIR-Spheres® Y-90 resin microspheres offers patients an opportunity to access radiotherapy for inoperable primary and secondary liver tumors whilst sparing normal liver parenchyma.