To watch the video in a different language click on the available version below:
Arabic | Dutch | French | German | Italian | Spanish | Turkish

Radiation is an effective way to destroy tumour tissues and is used widely in cancer treatment.

However, the organs and tissues in the body are sensitive to radiation and may also be damaged by radiation treatment. Thus, conventional radiotherapy (external beam radiation delivered from outside the body) can only be given to limited areas of the body.

The liver can only tolerate small doses of external radiotherapy. Because Selective Internal Radiation Therapy (SIRT) with SIR-Spheres® Y-90 resin microspheres targets the tumour(s) internally, it can deliver a larger dose of radiation directly over a longer time than is possible with external beam radiation. This allows therapeutic radiation to be targeted within the liver tumour(s).

Although normal liver tissue will be radiated to some extent, the radiation dose is well below the limit the tissue can tolerate without serious damage.

How do SIR-Spheres Y-90 resin microspheres get to the tumour?

Tumours get most of their blood supply from the hepatic artery, the main blood vessel that supplies blood to the liver. Normal liver tissue gets most of its blood supply from a blood vessel called the portal vein. Microspheres are injected into the hepatic artery so they are mainly delivered to the tumour.

Hepatic Artery

The microspheres become trapped in the very small blood vessels of the tumour where they deliver their radiation dose to an area of about 2-3mm around where they are trapped. Most of the radiation is delivered within 2 weeks. In this way, radiation is delivered mostly to the tumour but causes very little damage to the surrounding healthy liver tissue.

Hepatic Artery

Because the hepatic artery also supplies about 10-20% of the blood that goes to normal liver tissue, there is some radiation of this tissue. Your doctor will use a dose that will deliver radiation that is effective against the tumour but causes minimal or no damage to normal liver.

The microspheres only stay radioactive for a limited time. After 2 weeks only 3% of the initial radiation remains and after 1 month it all has decayed. The decayed resin microspheres stay in the liver permanently. They are harmless.


Now leaving

You are about to leave the Sirtex Web site. This link is provided to you as a service and will take you to a site maintained by a third party who is solely responsible for the content.

Please be aware that Sirtex takes no responsibility for content of these external sites, nor do we endorse, warrant or guarantee the products, services or information described or offered on other internet sites.

Click 'Continue' to proceed to the third-party Web site.



You are now leaving your current region

The Sirtex site you are linking to is intended only for healthcare practitioners and patients outside your current region. Any products discussed herein may have different approved product labeling; therefore, any information provided may not be appropriate for use in your region.

Click 'Continue' to proceed to the other Sirtex region Web site.