O Estudo SIRFLOX

O estudo SIRFLOX avaliou a eficácia e segurança da adição de Microsferas SIR-Spheres a uma quimioterapia sistêmica de primeira linha atual em pacientes com metástases hepáticas colorretais irressecáveis..

O SIRFLOX é o primeiro estudo de grande porte, randômico, controlado, aberto, multicêntrico e internacional para examinar o uso da quimiorradioterapia no tratamento de primeira linha da metástase hepática colorretal.

Com 530 pacientes recrutados, o SIRFLOX é o maior estudo randômico de radiologia intervencionista já realizado em oncologia.

Concepção do Estudo SIRFLOX

O SIRFLOX avaliou os benefícios para o paciente da adição de Microsferas SIR-Spheres a uma quimioterapia sistêmica atual de primeira linha compreendendo o mFOLFOX6 (com ou sem bevacizumab).

SIRFLOX recrutou pacientes sem experiência com quimioterapia com metástases hepáticas irressecáveis de câncer colorretal primário, com ou sem doença extra-hepática limitada.

A concepção do estudo SIRFLOX foi publicado em  BMC Cancer by Gibbs et al.




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