A localização primária do tumor no cólon é um importante fator prognóstico para o câncer colorretal precoce e avançado. Na última década, os pesquisadores descobriram que pacientes com mCRC que apresentam um tumor primário do lado direito (RSP) são mais difíceis de tratar, porque são menos responsivos às quimioterapias de atendimento padrão e têm menos opções de tratamento disponíveis, uma vez que o tumores não respondem a alguns agentes biológicos, como inibidores do EGFR (cetuximabe e panitumumabe1)

1. Clinical Practice Guidelines in Oncology (NCCN® Guidelines), Colon Cancer Version 2.2017 – March 13, 2017
https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf


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