Critérios Chave de Inclusão

Os critérios de seleção de pacientes para os três estudos foram semelhantes. Em FOXFIRE, não houve limitação no tamanho das metástases pulmonares ou linfonodais, e nenhuma restrição de órgãos das metástases hepáticas extras em comparação com FOXFIRE Global e SIRFLOX.

  • Tumores não ressecáveis somente fígado ou predominantes no fígado que se espalharam do cólon;
  • Sem quimioterapia prévia para doença avançada;
  • Ajuste para terapia combinada e terapia seletiva de radiação interna (SIRT).

Critérios Chave de Exclusão

  • Evidência de ascite, cirrose, hipertensão portal, envolvimento de tumor venoso porta principal ou trombose venosa porta principal
  • radioterapia prévia
  • Doença não maligna que torna os pacientes inadequados para o tratamento em estudo
  • Toxicidade prévia limitante de dose associada a quimioterapia adjuvante com 5-FU ou oxaliplatina
  • Grávida ou amamentando
  • malignidade simultânea ou anterior
  • Neuropatia periférica> grau 1 (NCI-CTCv3)

Wasan HS et al.  Lancet Oncol 2017; 18: 1159-71.


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