As diretrizes da ESMO e da NCCN recomendam microesferas de resina SIR-Spheres® Y-90 para tratamento de mCRC refratário ou intolerante à quimioterapia.

Diretriz de consenso da ESMO 2016

As microesferas de resina SIR-Spheres Y90 são recomendadas: 1 

  • para pacientes com mCRC com doença hepática limitada, com falha nas opções quimioterapêuticas disponíveis
  • como 'tratamento de consolidação' em linhas de tratamento anteriores (limitado a ensaios clínicos)

Atualmente, também pode ser uma boa alternativa para pacientes que são potenciais candidatos à ressecção, mas exibem um pequeno volume futuro de remanescente hepático (RPR).2

As evidências para a recomendação da ESMO sobre radioembolização são baseadas em estudos clínicos usando microesferas de resina SIR-Spheres Y-90.3

NCCN v1. 2017 Guidelines da prática clínica

As microesferas de resina SIR-Spheres Y90 são recomendadas para o câncer de cólon e retal, como uma opção em pacientes altamente selecionados com doença quimiorrefatora / resistente e com metástases hepáticas predominantes4

1. Van Cutsem E et al.  Annals of Oncology 2016; 27: 1386–1422.
2. Garlipp B et al. Hepatology 2014; 59:1864-1873.
3. Hendlisz A et al J Clin Oncol 2010; 28:3687-3694.
4. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology.  Colon Cancer Version 1, 2017.


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