Beyond first-line, there are multiple prospective studies and retrospective analyses which show the efficacy across multiple endpoints when SIR-Spheres Y-90 resin microspheres are used as a single agent, or in combination with chemotherapy.

Hendlisz et al. J Clin Oncol 2010; 28: 3687–94.  Seidensticker et al. Cardiovasc Interv Radiol 2012; 35; 1066‒73.  Cosimelli et al. Br J  Cancer 2010; 103: 324–31. Kennedy et al. J Gastrointest Oncol 2015; 6: 134‒42.

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