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mCRC Clinical Studies


mCRC Clinical Studies

SIR-Spheres® Y-90 resin microspheres have been extensively investigated in the treatment of liver metastases from colorectal cancer (mCRC).

SIR-Spheres in chemorefractory mCRC

  • Beyond first-line, multiple prospective studies and retrospective analyses have shown the efficacy across various endpoints when SIR-Spheres are used as a single agent, or in combination with chemotherapy.5-8

1. Van Hazel G et al. J Clin Oncol 2016; 34: 1723–1731.
2. Wasan HS et al. Lancet Oncol 2017; 18: 1159-1171
3. Gibbs P et al. Clin Col Cancer 2018; 17: e617-e629
4. Garlipp B et al. Br J Surg 2019; 106: 1837-1846.
5. Hendlisz A et al. J Clin Oncol 2010; 28: 3687–94.
6. Seidensticker R et al. Cardiovasc Interv Radiol 2012; 35; 1066‒73.
7. Cosimelli M et al. Br J Cancer 2010; 103: 324–31.
8. Kennedy A et al. J Gastrointest Oncol 2015; 6: 134‒42.



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New data available

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Increased Resectability in mCRC

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Increased OS in mCRC from right-sided primaries


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