Clinicians > mCRC Clinical Studies >
FOXFIRE Analysis


Key Findings

SIR-Spheres® Y-90 resin microspheres + mFOLFOX6 +/- biological*

  • did not add a benefit in Overall Survival1, but:
  • significantly increased Response Rate and median Progression Free Survival in the liver,1,2
  • resulted in a clinically relevant improvement in Overall Survival in patients with liver metastases from Right Sided Primary (RSP) tumours,
  • showed a Safety and Tolerability profile as expected and manageable.

*Bevacizumab in SIRFLOX and FOXFIRE Global, bevacizumab or cetuximab in FOXFIRE and biologicals allowed at investigator’s discretion, per institutional practice.

1. Wasan HS et al. Lancet Oncol 2017; 18: 1159-71
2. Van Hazel G et al. J Clin Oncol 2016; 34:1723–1731.


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