Clinicians > mCRC Clinical Studies > Right-Sided mCRC >
Overall Survival


Data from the 739 patient SIRFLOX and FOXFIRE Global studies indicate that OS was significantly improved by the addition of SIRT with liver-directed SIR-Spheres® Y-90 resin microspheres to first-line mFOLFOX6 chemotherapy (± bevacizumab) in mCRC patients with a Right-Sided Primary (RSP) tumour (median 22.0 vs. 17.1 months, with vs. without SIRT respectively; HR: 0.64 [95% CI: 0.46–0.89] p=0.007), which translates into a 36% reduction in the risk of death at any time compared to patients receiving chemotherapy alone.


Graph used with kind permission from Prof Guy van Hazel

No significant improvement in survival was seen from the addition of SIRT to first-line mFOLFOX6 chemotherapy for patients with Left-Sided Primary (LSP) tumours (median 24.6 vs. 26.6 months, with vs. without SIRT respectively; HR: 1.12 [95% CI: 0.92–1.36] p=0.279).


Graph used with kind permission from Prof Guy van Hazel

Van Hazel G et al. Ann Oncol 2017; ESMO 19th WCGIC, Abs. LBA-006.


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