The FOXFIRE Combined Analysis assessed the Overall Survival (OS) data from three randomised, controlled clinical studies FOXFIRE, FOXFIRE Global and SIRFLOX. These studies compared SIR-Spheres® Y-90 resin microspheres in combination with standard-of-care chemotherapy to chemotherapy alone in first-line treatment of metastatic colorectal cancer (mCRC).

The combined OS analysis was based on pooled data of 1,103 patients and examined a potential survival benefit from the addition of SIR-Spheres Y-90 resin microspheres to current chemotherapy. All three studies recruited chemotherapy-naïve patients with unresectable liver metastases from primary colorectal cancer, with or without limited extra-hepatic disease.

The data from the FOXFIRE Combined Analysis were presented in June 2017at American Society of Clinical Oncology (ASCO) and published in the Lancet Oncology in August 2017.1

SIRFLOX study design


The SIRFLOX study was the first large-scale, randomised controlled trial (RCT) of 530 chemotherapy-naïve patients with liver-only or liver-dominant mCRC which examined whether the combination of SIR-Spheres Y-90 resin microspheres with first-line chemotherapy was more effective than chemotherapy alone. The SIRFLOX study results were published in Journal Clinical of Oncology in early 2016.2 There was no statistically significant improvement in PFS at any site with the addition of SIR-Spheres Y-90 resin microspheres, a finding that was not unexpected with a liver-directed treatment. However, the risk of first progression in the liver as per competing risk analysis remained significantly lower for patients receiving SIR-Spheres Y-90 resin microspheres. The improvement was 7.9 month with an HR of 0.69 corresponding to a 31% reduction in risk of progression in the liver at any point in time.2

FOXFIRE study design


The FOXFIRE study randomised 364 patients, with unresectable, liver-only or liver-predominant mCRC, in 32 UK cancer centres. The study was initiated in 2010 by the Oxford Oncology Clinical Trials Office (OCTO) in collaboration with the UK National Cancer Research Institute and completed patient enrolment in 2014.3 In FOXFIRE, the use of the biologic agents bevacizumab or cetuximab were allowed at the investigator’s discretion and were stratified accordingly.

FOXFIRE Global study design


The FOXFIRE Global study enrolled 209 patients. The study began in 2013 in a network of more than 80 centres in Australia, New Zealand, Asia Pacific, Israel, Western Europe and the United States. The study completed patient enrolment in 2014.

1. Wasan HS et al. Lancet Oncol 2017; 18: 1159-71.
2. van Hazel GA et al. J Clin Oncol 2016; 34:1723–31.
3. Dutton SJ et al. BMC Cancer 2014; 14: 497.


Now leaving sirtex.com

You are about to leave the Sirtex Web site. This link is provided to you as a service and will take you to a site maintained by a third party who is solely responsible for the content.

Please be aware that Sirtex takes no responsibility for content of these external sites, nor do we endorse, warrant or guarantee the products, services or information described or offered on other internet sites.

Click 'Continue' to proceed to the third-party Web site.

Continue

×

You are now leaving your current sirtex.com region

The Sirtex site you are linking to is intended only for healthcare practitioners and patients outside your current region. Any products discussed herein may have different approved product labeling; therefore, any information provided may not be appropriate for use in your region.

Click 'Continue' to proceed to the other Sirtex region Web site.

Continue

×

This content is intended for healthcare professionals only

By clicking "Yes" you are confirming that you are a healthcare professional. If you are not a healthcare professional, then please click "Go to Homepage" which will direct you to the Sirtex homepage.

Yes Go to Homepage