The dose characteristics in the SIR-Spheres® Y-90 resin microspheres arm, were as follow:

Average cumulative lung dose per patient (range), Gy 2.6 (1.2-4.8)
Average activity delivered per session (range), GBq 0.95 (0.63–1.22)
Average activity delivered per patient (range), GBq 1.39 (0.99–1.85)

The activity was calculated using the modified Body-Surface Area (BSA) method.

71,7% of the treatments were lobar treatments and the majority (62,5%) were unilobar.



Patients with multiple sessions could have ipsi-lateral or contra-lateral treatment. 31.5% of the treatments were second-treatment and 6% were third-treatment, either ipsi- or contra-lateral.

In the sorafenib arm, the treatment characteristics were as follows:

Dose intensity, median (IQR), mg 800 (585–800)
Cumulative time of intake, median (IQR), months 2.8 (1.0–5.8)
Sorafenib dose reduction 38%
Permanent discontinuation rate (PDR) 61%
Including PDR prior to tumour progression 37%

Vilgrain V et al.  Lancet Oncol 2017; 18: 1624–36.



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