The dose characteristics in the SIR-Spheres® Y-90 resin microspheres arm, were as follow:

Average cumulative lung dose per patient (range), Gy 2.6 (1.2-4.8)
Average activity delivered per session (range), GBq 0.95 (0.63–1.22)
Average activity delivered per patient (range), GBq 1.39 (0.99–1.85)

The activity was calculated using the modified Body-Surface Area (BSA) method.

71,7% of the treatments were lobar treatments and the majority (62,5%) were unilobar.

Patients with multiple sessions could have ipsi-lateral or contra-lateral treatment. 31.5% of the treatments were second-treatment and 6% were third-treatment, either ipsi- or contra-lateral.

In the sorafenib arm, the treatment characteristics were as follows:

Dose intensity, median (IQR), mg 800 (585–800)
Cumulative time of intake, median (IQR), months 2.8 (1.0–5.8)
Sorafenib dose reduction 38%
Permanent discontinuation rate (PDR) 61%
Including PDR prior to tumour progression 37%

Vilgrain V et al.  Lancet Oncol 2017; 18: 1624–36.

Now leaving

You are about to leave the Sirtex Web site. This link is provided to you as a service and will take you to a site maintained by a third party who is solely responsible for the content.

Please be aware that Sirtex takes no responsibility for content of these external sites, nor do we endorse, warrant or guarantee the products, services or information described or offered on other internet sites.

Click 'Continue' to proceed to the third-party Web site.



You are now leaving your current region

The Sirtex site you are linking to is intended only for healthcare practitioners and patients outside your current region. Any products discussed herein may have different approved product labeling; therefore, any information provided may not be appropriate for use in your region.

Click 'Continue' to proceed to the other Sirtex region Web site.



This content is intended for healthcare professionals only

By clicking "Yes" you are confirming that you are a healthcare professional. If you are not a healthcare professional, then please click "Go to Homepage" which will direct you to the Sirtex homepage.

Yes Go to Homepage