SIRFLOX Key Findings


SIR-Spheres® Y-90 resin microspheres + mFOLFOX6 (+ bev*) in mCRC

  • No statistically significant improvement of PFS at any site.1
  • Statistically significant improvement of 7.9 months in median PFS in the liver, from 12.6 to 20.5 months representing a 31% reduction in risk of progression in the liver.1
  • Statistically significant increase of hepatic Depth of Response (DpR) by 20% in patients with >12% tumour burden and >100 day improvement in Time to Nadir compared to chemotherapy alone.2
  • Three-fold increase in complete response rate in the liver.1
  • Statistically significant increase in hepatic response rate.1

bev*: bevacizumab (bevacizumab allowed at investigator’s discretion, per institutional practice)
1. van Hazel GA et al. J Clin Oncol 2016; 34: 1723–1731.
2. Heinemann V et al. ESMO WCGIC, Annals of Oncology 2016; 27 (Suppl 2): Abs. O-014.


The SIRFLOX data were presented at ASCO 2015 by Professor Peter Gibbs, The Royal Melbourne Hospital, Australia, Co-Principal Investigator.


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