Published Data in Metastatic Ocular Melanoma

SIR-Spheres® Y-90 resin microspheres have shown benefits in the first-line treatment of treatment-refractory liver metastases from melanoma (predominantly from ocular or uveal primary tumours).

In a mixed population of patients with unresectable cutaneous or ocular metastatic melanoma that was refractory to systemic therapy, SIR-Spheres Y-90 resin microspheres were associated with longer survival from diagnosis of the metastatic melanoma than best supportive care (19.9 months vs. 4.8 months).1 Other non-comparative studies of SIRT with SIR-Spheres Y-90 resin microspheres for metastatic melanoma have demonstrated similar or longer survival from diagnosis (19.0–23.9 months).2,3

SIR-Spheres Y-90 resin microspheres are generally well tolerated in this clinical setting.

Summary of SIR-Spheres Y-90 resin microspheres in mOM

1 Xing M. et al. Am J Clin Oncol 2014 Aug 1; ePub doi: 10.1097/COC.0000000000000109.
2 Klingenstein A. et al. Cardiovasc Intervent Radiol 2013; 36: 158-165.
3 Eldredge-Hindy H. et al. Am J Clin Oncol 2016; 39: 189-195.

Ongoing mOM Studies

Ongoing studies of SIR-Spheres® Y-90 resin microspheres in the treatment of mOM:

Title Setting Sponsor Study ID Treatment Arm(s) N Location
SIRUM (TJU)
SIR-Spheres microspheres treatment of uveal melanoma metastasised to liver
Uveal melanoma Investigator-Initiated Research Study NCT01473004 SIR-Spheres Y-90 resin microspheres 48 USA
SIRTAC
SIR-Spheres microspheres vs. TACE treatment of uveal melanoma metastasised to liver
Uveal melanoma Investigator-Initiated Research Study NCT02936388 SIR-Spheres Y-90 resin microspheres vs. TACE (cisplatin+embocept) 108 Germany
SORASIRT
Sorafenib and radioembolisation with SIR Spheres for the treatment of metastatic ocular melanoma
Uveal melanoma Investigator-Initiated Research Study NCT01893099 SIR Spheres Y-90 resin microspheres > sorafenib or sorafenib > SIR Spheres Y-90 resin microspheres 24 Switzerland

 



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